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Washington University in St. Louis School of Medicine Division of Biology and Biomedical Sciences Division of Biology and Biomedical Sciences
Division of Biology and Biomedical Sciences Division of Biology and Biomedical Sciences
Thomas J. Brett, Ph.D.

Assistant Professor (PEFA)
Internal Medicine
Assistant Professor
Cell Biology and Physiology
Assistant Professor
Biochemistry and Molecular Biophysics
Biochemistry Program
Immunology Program
Office Phone: 314-747-0018
Lab Phone: 314-747-0049
Other Phone: 314-362-9047
FAX:
Box: 8052
Lab Address: CSRB 10046
Email: tbrett@wustl.edu
Keywords: biophysics; crystallography; molecular medicine; endocytosis; receptor trafficking; structural biology
Research Abstract:


Selected Publications:
Patel AC, Brett TJ and Holtzman MJ. The role of CLCA proteins in inflammatory airway disease. Annual Review of Physiology 2009 71: 425-449.

Brett TJ and Traub LM. Molecular structures of coat and coat-associated proteins: function follows form. Current Opinion in Cell Biology 2006 18: 395-406.

Brett TJ, Legendre-Guillemin V, McPherson PS and Fremont DH. Structural definition of the F-actin-binding THATCH domain from HIP1R. Nature Structural & Molecular Biology 2006 13: 121-130.

Ota N, Brett TJ, Murphy TL, Fremont DH and Murphy KM. N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Nature Immunology 2004 5: 208-215.

Brett TJ, Traub LM and Fremont DH. Accessory protein recruitment motifs in clathrin-mediated endocytosis. Structure (Camb) 2002 10: 797-809.

Last Updated: 08/12/2009