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microRNAs, post-mitotic neurons, regenerative medicine, neurogenesis, stem cell

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The general goal of my research is to understand molecular mechanisms underlying the specification of cell types and developing methods to alter the fates of cells in vitro and in vivo. We recently discovered that small RNA molecules, microRNAs, could promote the generation of post-mitotic neurons by demonstrating that expression of neuron-specific microRNAs and neural factors in non-neuronal cell types could directly reprogram their cell fates into functional neurons. In my independent laboratory, I plan to develop tissue culture models of neurological diseases using patient-specific neurons and to study the cell autonomous properties of the induced neurons associated the disease states. Another goal is to identify the molecular mechanisms underlying the neurogenic activities of the neuron-specific microRNAs. We will use multiple interdisciplinary approaches (molecular genetics, genomics and biochemistry) to delineate how these microRNAs promote neuronal fates.

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Andrew Yoo

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Direct reprogramming of cell fates using microRNAs and neural factors

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Date Last Updated

11/9/2011 4:45 PM


Yoo, A.S.*, Sun, A.X., Li, L., Shcheglovitov, A., Portmann, T., Li, Y., Lee-Messer, C., Dolmetsch, R.E., Tsien, R.W., and Crabtree, G.R.* (2011). MicroRNA-mediated conversion of human fibroblasts to neurons. Nature 476, 228-231. * Co-corresponding author (PMCID: 21753754) Choi, M.S., Yoo, A.S., and Greenwald, I. (2010). sel-11 and cdc-42, two negative modulators of LIN-12/Notch activity in C. elegans. PLoS One 5, e11885. (PMCID: 20686701) Yoo, A.S., Staahl, B.T., Chen, L., and Crabtree, G.R. (2009). MicroRNA-mediated switching of chromatin-remodelling complexes in neural development. Nature 460, 642-646. (PMCID: 19561591) Yoo, A.S., and Crabtree, G.R. (2009). ATP-dependent chromatin remodeling in neural development. Curr Opin Neurobiol 19, 120-126. (PMCID: 19442513) Yoo, A.S., and Greenwald, I. (2005). LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans. Science 310, 1330-1333. (PMCID: 16239437) Yoo, A.S., Bais, C., and Greenwald, I. (2004). Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science 303, 663-666. (PMCID: 14752159) Yu, H., Yoo, A.S., and Greenwald, I. (2004). Cluster Analyzer for Transcription Sites (CATS): a C++-based program for identifying clustered transcription factor binding sites. Bioinformatics 20, 1198-1200. (PMCID: 14764556) Yoo, A.S., Cheng, I., Chung, S., Grenfell, T.Z., Lee, H., Pack-Chung, E., Handler, M., Shen, J., Xia, W., Tesco, G., et al. (2000). Presenilin-mediated modulation of capacitative calcium entry. Neuron 27, 561-572. (PMCID: 11055438)

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An example of human neurons converted from dermal fibroblasts

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Created at 11/9/2011 4:45 PM by DBBS_SP_SAPP
Last modified at 11/10/2011 10:36 AM by Kathryn Ruzicka