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University ID

 6177

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 Yes

Full Name

  

First Name

 Eric

Last Name

 Galburt

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Faculty Keyword

 biophysics, molecular motors, optical trapping, pre-mRNA alternative splicing, RNA, transcription

Office Phone

 314-362-5201

Lab Phone

 314-362-4821

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Lab Address

 660 South Euclid Avenue

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Research Abstract
Work in my laboratory combines biochemical and biophysical techniques to shed light on the detailed interactions between macromolecules that are central to the biology of all organisms. In particular we use single-molecule techniques such as optical and magnetic trapping in combination with fluorescent methods to understand the detailed molecular mechanisms of biological processes. Current projects in the lab include: - Transcription elongation and pausing - Co-transcriptional RNA folding - Eukaryotic transcription initiation

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 A.

Public Name

 Eric A. Galburt

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Campus Box

 8231

Website Url

 http://biochem.wustl.edu/~egalburt/

Ten Word Res Desc
Cotranscriptional RNA folding; Intron splicing; Transcription; Single Molecule; Optical Trapping; Magnetic Trapping; Biophyiscs

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Date Last Updated

 11/10/2011 10:54 AM

Publications
Galburt EA, Parrondo, Grill SW.  RNA polymerase pushing. Biophysical Chemistry 2011 157(1-3):43-47.
 
Depken M, Galburt EA, Grill SW.  The origin of short transcriptional pauses. Biophysical Journal 2009 1896(6):2189-93. PMCID: PMC2717293
 
Galburt EA, Grill SW, Bustamante C. Single molecule transcription elongation. Methods 2009 Aug;48(4):323-32. Epub 2009 May 6.PMCID:PMC2767109
 
Galburt EA, Grill SW, Wiedmann A, Lubkowska L, Choy J, Nogales E, Kashlev M and Bustamante CJ.  Backtracking determines the force sensitivity of RNAP II in a factor-dependent manner. Nature 2007 446(7137):820-3.
 
Galburt EA, Pelletier J, Wilson G and Stoddard BL.  Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase. Structure 2002 10(9):1249-60.

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 http://dbbs.wustl.edu/Faculty Photos Thumbnail/Galburt_E.jpg

Profile_Image_Url

 http://dbbs.wustl.edu/Faculty Photos/Galburt_E.jpg

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Approval Status Approved
 

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Created at 11/10/2011 10:54 AM by DBBS_SP_SAPP
Last modified at 11/10/2011 12:56 PM by Kathryn Ruzicka