Skip Ribbon Commands
Skip to main content

DBBS

:

FacultyList: (no title)

Title

 

University ID

5993

ShowOnHomePage

Yes

Full Name

 

First Name

Vladimir

Last Name

Kefalov

Degree

 

Faculty Keyword

photoreceptors, physiology, signal transduction, retina, vision, neurodegeneration

Office Phone

314-362-4376

Lab Phone

314-747-9041

Other Phone

 

Fax

314-747-9046

Lab Address

McMillan Bldg, Room 625

Email

 

Research Abstract

We derive most of our information about the world through our visual system by means of rod and cone photoreceptors. The human retina has one type of rod for dim light vision, and three types of cone cells that allow color discrimination. Despite the similarities in their morphology and mechanism of light detection, rods and cones have distinct functional properties. Rods are extremely sensitive (they can detect a single photon of light!) and thus are perfectly suited for dim light conditions. They saturate in moderate light, however, and are not able to respond to light through most of the day. Cones, on the other hand, are 30-100 times less sensitive than rods and do not respond to light in dim light conditions (this is why we don’t see colors at night). However, cones are capable of adapting to an extremely wide range of light conditions, rendering them perfectly suited as our daytime photoreceptors. Our lab is interested in the mechanisms that determine the functional properties of mammalian rod and cone photoreceptors. We use a battery of tools, from single-cell and isolated retina recordings, to live electroretinogram and behavior experiments with wild type and genetically modified mice. While the emphasis of our studies is on our daytime photoreceptors, the cones, we are also investigating some aspects of rod phototransduction.

Middle Initial

J.

Public Name

Vladimir J. Kefalov

Doctoral Degree1

 

Doctoral Degree2

 

Primary Title

 

Secondary Title

 

Third Title

 

Fourth Title

 

Primary Department

 

Secondary Department

 

Third Department

 

Fourth Department

 

Division Primary Department

 

Campus Box

8096

Website Url

http://vr-core.wustl.edu/Pages/Kefalov-Lab.aspx

Ten Word Res Desc

Physiology of photoreceptors

Micro Category1

 

Micro Category2

 

Micro Category3

 

Plant Category

 

Comp Category

 

DBBS Faculty

 

Archived Faculy Flag

 

Date Last Updated

11/10/2011 11:03 AM

Publications

Sakurai K, Chen J, Kefalov VJ.  Role of guanylyl cyclase modulation in mouse cone phototransduction. J Neurosci. 2011 31(22): 7991-8000. MCID: PMC3124626
 
Kolesnikov AV, Tang PH, Parker RO, Crouch RK, Kefalov VJ.  The mammalian cone visual cycle promotes rapid M/L-cone pigment regeneration independently of the interphotoreceptor retinoid-binding protein. J Neurosci. 2011 31(21): 7900-9. PMCID: PMC3108150
 
Kolesnikov AV, Fan J, Crouch RK, Kefalov VJ.  Age-related deterioration of rod vision in mice. J Neurosci. 2010 30(33): 11222-31. PMCID: PMC2928554
 
Wang JS, Kefalov VJ.  An alternative pathway mediates the mouse and human cone visual cycle. Curr Biol. 2009 19(19): 1665-9. PMCID: PMC2762012
 
Wang JS, Estevez ME, Cornwall MC, Kefalov VJ.  Intra-retinal visual cycle required for rapid and complete cone dark adaptation. Nat Neurosci. 2009 12(3): 295-302. PMCID: PMC2707787

Show Bio Page

Yes

Exclude Email

No

Thumbnail_Image_Url

http://dbbs.wustl.edu/Faculty Photos Thumbnail/Kefalov_V.jpg

Profile_Image_Url

http://dbbs.wustl.edu/Faculty Photos/Kefalov_V.jpg

Primary Program

 

Secondary Program

 

Teritiary Program

 

Fourth Program

 

Fifth Program

 

Research Image Description

Acute treatment with the gliotoxin L-α-AAA kills most Müller glial cells in the mouse retina as demonstrated by Müller cell-specific immunolabeling. Missing Müller cell nuclei in right panel are indicated by arrowheads. Removal of Müller glia blocks the ability of the retina to promote cone pigment regeneration demonstrating the critical role these cells play in the recycling of chromophore within the neural retina.

Research Image Url

http://dbbs.wustl.edu/Faculty Research Images/Vladimir_Kefalov_5993.jpg

Social Media Url

 
Approval Status Approved
 

Attachments

Created at 11/10/2011 11:03 AM by DBBS_SP_SAPP
Last modified at 11/10/2011 1:01 PM by Kathryn Ruzicka