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Title

 

University ID

6112

ShowOnHomePage

Yes

Full Name

 

First Name

Elizabeth

Last Name

Haswell

Degree

 

Faculty Keyword

gravitropism, mechanotransduction, mechanosensitive ion channels, molecular genetics, organelle morphology

Office Phone

314-935-9223

Lab Phone

314-935-9634

Other Phone

 

Fax

 

Lab Address

249 McDonnell Hall

Email

 

Research Abstract

Cells and organisms must sense and respond to mechanical forces generated outside the cell (shear force, gravity, touch) as well as inside the cell (osmotic pressure, membrane deformation). The Haswell lab is interested in how physical force is converted into a biochemical signal capable of altering the state of a cell. We are addressing this question in the model plant Arabidopsis thaliana, where a number of important mechanical signal transduction pathways have been characterized. We use an array of biochemical and molecular genetic approaches, electrophysiology, and state-of-the-art live imaging methodologies in our experiments. Three main lines of inquiry in the lab are:
 
1) functional characterization of a family of mechanosensitive ion channels related to the bacterial channel MscS;
 
2) genetic approaches to identifying new components of gravity and touch signal transduction pathways; and
 
3) investigation into the role played by mechanosensory systems in organelle shape and size determination.

Middle Initial

S.

Public Name

Elizabeth S. Haswell

Doctoral Degree1

 

Doctoral Degree2

 

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Division Primary Department

 

Campus Box

1137

Website Url

http://biology4.wustl.edu/faculty/haswell/

Ten Word Res Desc

Mechanotransduction in plants and bacteria

Micro Category1

 

Micro Category2

 

Micro Category3

 

Plant Category

 

Comp Category

 

DBBS Faculty

 

Archived Faculy Flag

 

Date Last Updated

11/10/2011 3:43 PM

Publications

Wilson ME & Haswell ES.  A Role for Mechanosensitive Channels in Chloroplast and Bacterial Fission.  Plant Signaling and Behavior 2011 (In Press).
 
Maksaev G & Haswell ES.  Expression and Characterization of the Bacterial Mechanosensitive Channel MscS in Xenopus laevis Ooctyes.  Journal of General Physiology 2011 (In Press).
 
Haswell ES, Phillips R & Rees DC.  Mechanosensitive Channels: What Can They Do and How Do They Do It?  Structure 2011 19: 1356-1369.
 
Wilson ME, Jensen GS & Haswell ES. Two Mechanosensitive Channel Homologs Influence FtsZ Ring Placement in Arabidopsis.  The Plant Cell 2011 23:2 939-2949.
 
Peyronnet R, Haswell ES, Barbier-Brygoo H and Frachisse J-M. AtMSL9 and AtMSL10: Sensors of Plasma Membrane Tension in Arabidopsis Roots. Plant Signaling and Behavior 2008 3: 726-729.
 
Haswell ES*, Peyronnet* R, Barbier-Brygoo H, Meyerowitz EM and Frachisse J-M. Two MscS Homologues Required for Mechanosensitive Channel Activities in the Arabidopsis Root. Current Biology 2008 18: 730-734. *equal contribution
 
Haswell ES. MscS-like Proteins in Plants. Current Topics in Membranes 2007 58:329-359.
 
Haswell ES and Meyerowitz EM. MscS-like Proteins Control Plastid Size and Shape in Arabidopsis thaliana. Current Biology 2006 16:1-11.
 
Haswell ES. Gravity Perception: How Plants Stand up for Themselves. Current Biology 2003 13:R761-R763.

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Exclude Email

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Thumbnail_Image_Url

http://dbbs.wustl.edu/Faculty Photos Thumbnail/Haswell_E.jpg

Profile_Image_Url

http://dbbs.wustl.edu/Faculty Photos/Haswell_E.jpg

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Research Image Description

Abnormal FtsZ ring formation in Arabidopsis chloroplasts lacking functional mechanosensitive channels

Research Image Url

http://dbbs.wustl.edu/Faculty Research Images/Elizabeth_Haswell_6112.jpg

Social Media Url

 
Approval Status Approved
 

Attachments

Created at 11/10/2011 3:43 PM by DBBS_SP_SAPP
Last modified at 11/11/2011 9:06 AM by Kathryn Ruzicka