Three antibiotics that, individually, are not effective against a drug-resistant staph infection can kill the deadly pathogen when combined as a trio, according to new research.
The researchers, at Washington University School of Medicine
in St. Louis, have killed the bug — methicillin-resistantStaphylococcus aureus
(MRSA) — in test tubes and laboratory mice, and believe the same three-drug strategy may work in people.
“MRSA infections kill 11,000 people each year in the United States, and the pathogen is considered one of the world’s worst drug-resistant microbes,” said principal investigator Gautam Dantas, PhD, an associate professor of pathology and immunology. “Using the drug combination to treat people has the potential to begin quickly because all three antibiotics are approved by the FDA.”
The study is published online Sept. 14 in the journal Nature Chemical Biology.