Pathobiology of Human Disease States Course Information

Welcome to the Homepage for the Markey Pathway course at Washington University School of Medicine.  
The course meets every Tuesday and Thursday during the fall semester.  Markey students should register for 2.0 units of L41 Bio 5191. 

**Please note that acceptance into the Markey Pathway is required to attend the course**
Information about the course & how to apply can be found at:
http://dbbs.wustl.edu/curstudents/SpecialEmphasisPathways/Pages/Markey.aspx

Course Location:  FLTC 205 - Farrell Learning & Teaching Center, Room 205
Date(s):  08/27/2019 - 11/19/2019 Tuesdays & Thursdays ONLY
Time:  1:30 PM - 3:00 PM, Unless Noted on the Schedule

Class attendance is required. Please check the schedule for class time changes or alternate locations (will be displayed in red).

Mandatory Clinical Mentorship Orientation – 
Thurs. Dec. 12 from 1 – 2 p.m.
Schwarz Conference Room, Maternity Hospital (McMillan), Floor 1
Please, mark your calendar, as this is a requirement for all students. ​​​

Fall 2019 Class Topics:

Section 1:  Immunotherapy
Section 2:  Diabetes
Section 3:  Retina

Section I - Immunotherapy

Section Co-Leaders:
Todd Fehniger, M.D., Ph.D., Associate Professor of Medicine, Division of Oncology, Bone Marrow Transplant;
Nathan Singh, M.D., Assistant Professor of Medicine, Division of Oncology, Stem Cell Biology

​Date

​Location

​Speaker

Topic​

Aug. 27

FLTC 205
(1:30-3:00pm)

Todd Fehniger, MD, PhD

Associate Professor of Medicine, Division of Oncology, Bone Marrow Transplant

Intro to Immunotherapy Module and Natural Killer Cell Therapy

​Aug. 29

FLTC 205
(1:30-3:00pm)

Amanda Cashen, MD

Associate Professor, Medicine

Division of Oncology, Bone Marrow Transplant

Hematopoietic Cell Transplantation

 

Patient Visit

​Sept. 3

FLTC 205
(1:30-3:00pm)

Nathan Singh, MD

Assistant Professor of Medicine, Division of Oncology, Stem Cell Biology

Chimeric Antigen Receptor

(CAR) T Cell Therapy 

Patient Visit

Sept. 5

FLTC 205
(1:30-3:00pm)

Carl DeSelm, MD, PhD

Assistant Professor of Radiation Oncology, Division of Cancer Biology

 

Engineered APCs

Sept. 10

LOCATION & TIME CHANGE: 

Lobby, CAM

(1-3:00PM)

FIELD TRIP 

Tour of apheresis center, cell therapy lab, biological therapy facility (GMP), and 8800 Clinical Cell Therapy Unit

 “Follow The Cells!” 

 

(Note: 2 hours!)

Sept. 12

FLTC 205

(1:30-3:00pm)

David DeNardo, PhD

Associate Professor, Medicine
Division of Oncology
ICCE Institute

Andrea Wang-Gillam, MD PhD

Associate Professor, Medicine
Division of Oncology
Section: Medical Oncology

Tumor Microenvironment

Patient Visit

Sept. 17

FLTC 205
(1:30-3:00pm)

Tanner Johanns, MD, PhD

Instructor, Department of Medicine, Division of Oncology

 

 

Immune Checkpoint Therapy and Neo-Antigen Vaccines

 

Patient Visit

​Sept. 19

FLTC 205
(1:00 -2:30pm)

ALL

Wrap up discussion and lunch


​​

Section II - Diabetes

Section Leaders:
Thomas J. Baranski, M.D., Ph.D., Associate Professor of Medicine & Developmental Biology, Division of Endocrinology, Metabolism, & Lipid Research
Charlie Harris, M.D., Ph.D., Assistant Professor of Medicine, Division of Endocrinology, Metabolism, & Lipid Research 

Date

Location

Speaker​

Topic

Sept 24

FLTC 205 (1:30-3:00pm)

Colin Nichols, PhD

Carl Cori Professor of Cell Biology & Physiology CIMED Director

Division of Cell Biology & Physiology

Monogenic Diabetes

Sept 26

FLTC 205 (1:30-3:00pm)

Jeff Millman, PhD

Assistant Professor of Medicine & Biomedical Engineering Division of Endocrinology, Metabolism, & Lipid Research

Pluripotent Technologies and Beta Cells

Oct 1

FLTC 205 (1:45-3:15pm)

Fumi Urano, MD PhD

Samuel E. Schechter Professor of Medicine

Division of Endocrinology, Metabolism, & Lipid Research

Wolfram Syndrome Patient Visit

Oct 3

FLTC 205 (1:30-3:00pm)

Paul Hruz, MD PhD

Director, Division of Pediatric Endocrinology & Diabetes Associate Professor of Pediatrics: Endo & Metabolism + Cell Biology & Physiology

Insulin Action-lessons from Transgenic Animals

Oct 8

FLTC 205 (1:30-3:00pm)

Charles Harris, MD PhD

Assistant Professor of Medicine Division of Endocrinology, Metabolism & Lipid Research

Obesity & Insulin Resistance

Oct 10

FLTC 205 (1:30-3:00pm)

Tom Baranski, MD PhD

Associate Professor of Medicine & Developmental Biology Division of Endocrinology, Metabolism, & Lipid Research

Complications of Diabetes Patient Visit

Oct 15

N/A

Fall Break

No Class

Oct 17

FLTC 205 (1:30-3:00pm)

Garry Tobin, MD

Associate Professor of Medicine Director, Diabetes Center Division of Endocrinology, Metabolism, & Lipid Research

Introduction to Clinical Diabetes Patient Visit

Oct 22

FLTC 205 (1:30-3:00pm)

ALL

Faculty Overview and Course Discussion

 

Lunch served


​​​

Section III - Retina

Section Leaders:
Rithwick Rajagopal, M.D., Ph.D., Assistant Professor, Ophthalmology and Visual Sciences
Lynn Hassman, M.D., Ph.D., Assistant Professor, Ophthalmology and Visual Sciences Research
 

Date

Location

Speaker

Topic

Oct 24

FLTC 205 (1:30-3:00pm)

Rithwick Rajagopal, MD PhD

Assistant Professor, Ophthalmology and Visual Sciences

 

Overview of modern imaging techniques of the retina and choroid

Oct 29

FLTC 205 (1:30-3:00pm)

Gregory Van Stavern, MD

Professor, Ophthalmology and Visual Sciences

Overview of modern diagnostic visual electrophysiology

Oct 31

FLTC 205 (1:30-3:00pm)

Kisha Piggott, MD PhD

Assistant Professor, Ophthalmology and Visual Sciences; Assistant Residency Program Director

 

Tumors of the retina and choroid

Nov 5

FLTC 205 (1:30-3:00pm)

Joseph C. Corbo, MD PhD

Professor, Pathology and Immunology, Genetics, Ophthalmology and Visual Sciences

Inherited retinal diseases

Nov 7

FLTC 205 (1:30-3:00pm)

Rajendra Apte, MD PhD

Paul A. Cibis Distinguished Professor of Ophthalmology and Visual Sciences

Diseases associated with the aging retina

Nov 12

FLTC 205 (1:30-3:00pm)

P. Kumar Rao, MD

Professor of Ophthalmology and Visual Sciences

Infectious uveitis

Nov 14

FLTC 205 (1:30-3:00pm)

Lynn Hassman, MD, PhD Assistant Professor, Ophthalmology and Visual Sciences Research

Precision medical management of non-infectious uveitis

Nov 19

FLTC 205 (1:30-3:00pm)

Rithwick Rajagopal, MD PhD

Faculty Overview and Course Discussion

 

Lunch served

 ​

​​​​

Past Course Modules

Year
Modules
1992
1. Sickle Cell Anemia
2. Malaria​
3. Diabetes
1993
1. Cystic Fibrosis
2. Coronary Artery Disease
3. AIDS
1994
1. Sickle Cell Anemia
2. Emphysema
3. Acute Leukemia 
1995
1. Multiple Endocrine Neoplasia
2. Undue Susceptibility to Infection
3. Alzheimer’s Disease
1996
1. Sickle Cell Disease
2. Multiple Sclerosis
3. Epstein Barr Virus
1997
1. Osteoporosis
2. Thrombophilia
3. Congenital Malformations
1998
1. Sickle Cell Disease
2. Hepatitis C
3. Chronic Myelogenous Leukemia
1999
1. Rheumatoid Arthritis
2. AIDS
3. Prostate Cancer
2000
1. Sickle Cell Disease
2. Epstein Barr Virus
3. Heart Failure
2001
1. Alzheimer’s Disease
2. Chronic Myelogenous Leukemia
3. SLE (Lupus)
2002
1. Heart Failure
2. Diabetes Mellitus
3. Preeclampsia
2003
1. SLE/Rheumatoid Arthritis
2. Chronic Myelogenous Leukemia
3. Asthma
2004
1. AIDS
2. Heart Failure
3. Preeclampsia
2005
1. Alzheimer’s Disease
2. Breast Cancer
3. Rheumatoid Arthritis
2006
1. Sickle Cell Anemia
2. Congestion Heart Failure
3. High Risk Pregnancy
2007
1. Rheumatoid Arthritis
2. Chronic Myelogenous Leukemia
3. Alzheimer’s Disease
2008
1. Cardio Disease/Heart Failure
2. Diabetes & Metabolism
3. Osteoporosis/Other Bone Disorders
2009
1. Sickle Cell Anemia
2. AIDS
3. Major Depressive Disorders
2010
1. Alzheimer’s Disease
2. Cardio Disease/Heart Failure
3. Diabetes
2011
1. Chronic Myelogenous Leukemia
2. Cystic Fibrosis
3. High Risk Pregnancy
2012
1. Rheumatoid Arthritis
2. Cardiovascular Disease
3. Malaria
2013
1. Diabetes
2. High Risk Pregnancy
3. Depression
2014
1. Translating Global Health
2. Cardiovascular Disease
3. Chronic Myelogenous Leukemia
2015
1. Immunotherapy
2. High Risk Pregnancy
3. Alzheimer’s Disease
2016
1. Evidence Based Medicine/Sickle Cell Disease
2. Diabetes
3. Cardiovascular Disease
​2017 ​​1. Immunotherapy
2. Alzheimer's Disease
3. Cardiovascular Disease
​2018 ​​1. High Risk Pregnancy
2. Pain Management
3. Cardiovascular Disease

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