Pathobiology of Human Disease States Course Information

Welcome to the Homepage for the Markey Pathway course at Washington University School of Medicine.  
The course meets every Tuesday and Thursday during the fall semester.  Markey students should register for 2.0 units of L41 Bio 5191. 

**Please note that acceptance into the Markey Pathway is required to attend the course**
Information about the course & how to apply can be found at:
http://dbbs.wustl.edu/curstudents/SpecialEmphasisPathways/Pages/Markey.aspx

Course Location: All 2020 classes will be conducted via HIPAA protected Zoom
Date(s):  09/15/2020 - 12/03/2020 Tuesdays & Thursdays
Time:  1:30 PM - 3:00 PM, All exceptions are noted in red

Class attendance is required.

Mandatory Clinical Mentorship Orientation – Thursday, 12/10/2020 at 1:30pm

Fall 2020 Class Topics:  Alzheimer Disease, Hearing Loss, Cardiovascular Disease

Section I - Alzheimer Disease

Section Leaders:
Joy Snider, MD, PhD, Professor, Neurology;
Nupur Ghoshal, MD, PhD, Associate Professor, Neurology & Psychiatry

​Date

​Location

​Speaker

Topic​

Sept 15 @ 1:30PM

Zoom

John C. Morris, MD
Harvey A. & Dorismae Hacker Friedman Professor of Neurology

Professor, Pathology & Immunology

Introduction to Alzheimer’s Disease

 

Patient Visit

Sept 17 @ 1:30PM

Zoom

 

John Cirrito​, PhD
Associate Professor, Neurology

Anne Fagan, PhD
Professor, Neurology

Abeta and tau metabolism/fluid biomarkers in Alzheimer’s Disease

Sept 22

NO CLASS

Wednesday

Sept 23 @ 1:30PM

Zoom

Timothy Miller, MD PhD
David Clayson Professor of Neurology


David Holtzman, MD
Andrew B and Gretchen P Jones Professor and Chair of Neurology

RNA targeted therapeutic strategies for dementia 

 

Propagation of misfolded proteins

Sept 24 @ 1:30PM

Zoom

Brendan Lucey, MD
Associate Professor, Neurology

Joy Snider MD, PhD
Professor, Neurology

Sleep science and dementias 

 

Clinical trials in dementia

Sept.29 @ 1:30PM

Zoom

Nupur Ghoshal, MD PhD
Associate Professor, Neurology

Non AD dementias

Oct 1 @ 1:30PM

Zoom

Cyrus Raji, MD, PhD
Assistant Professor, Radiology

Imaging in dementia

Oct 6 @ 1:30PM

Zoom

Richard Dunham, MD
Assistant Professor, Neurology 

Autoimmune causes of dementia and rapidly progressive dementias 

Patient Visit

Oct 8

Zoom

ALL

Wrap up discussion & lunch

Section II - Hearing Loss

Section Leaders:
Keiko Hirose, MD,
Professor, Otolaryngology, Chief, Pediatric Otolaryngology
Mark Rutherford, PhD, Assistant Professor, Otolaryngology

​Date

​Speaker

Topic​

​Moderator

Oct 13

Craig Buchman, MD
Li​ndburg Professor & Chair, Otolaryngology

Intro to Auditory System

+ Guest CI pediatric patient

Mark Rutherford

Oct 15

Pablo Blazquez, PhD
Associate Professor Otolaryngology

Jonathan Peelle, PhD
Associate Professor Otolaryngology

Vestibular Physiology

Cognitive Consequences of Hearing Loss

Keiko Hirose

Oct. 20

MichaelAnne Gratton, PhD
Professor, Otolaryngology

Kevin Ohlemiller, PhD
Associate Professor of Otolaryngology

Prebycusis

Noise-induced hearing loss

Mark Rutherford

 

Oct 22

Konstantina Stankovic, MD, PhD, FACS
Associate Professor of Otolaryngology
Harvard Medical School

Keiko Hirose, MD
Professor, Otolaryngology
Chief, Pediatric Otolaryngology

Physician Scientist Pathway


Cochlear Inflammation

Keiko Hirose

Oct.27

Mark Rutherford, PhD
Assistant Professor, Otolaryngology

Mark Warchol, PhD
Professor, Otolaryngology
Professor, Anatomy & Neurobiology

Excitotoxicity and Synaptopathy

Regeneration, Repair

Mark Rutherford

Oct. 29

Jeffrey Holt, PhD
Professor of Otolaryngology and Neurology
Boston Children’s Hospital, Harvard Program in Neuroscience

Tatyana Yakusheva, PhD
Assistant Professor, Otolaryngology

Mechanotransdution


Vestibular Behavior

Keiko Hirose

Nov 3

Lavinia Sheets, PhD
Assistant Professor, Otolaryngology

Tobias Moser, MD
Göttingen Graduate Center for Neursciences, Institute for Auditory Neuroscience and InnerEarLab

Genetics of Deafness, Gene Therapy

Optical Cochlear Implant

 

Mark Rutherford

Nov 5

ALL

Wrap up Discussion

Keiko Hirose

Section III - Cardiovascular Disease

TBA

Past Course Modules

Year
Modules
1992
1. Sickle Cell Anemia
2. Malaria​
3. Diabetes
1993
1. Cystic Fibrosis
2. Coronary Artery Disease
3. AIDS
1994
1. Sickle Cell Anemia
2. Emphysema
3. Acute Leukemia 
1995
1. Multiple Endocrine Neoplasia
2. Undue Susceptibility to Infection
3. Alzheimer’s Disease
1996
1. Sickle Cell Disease
2. Multiple Sclerosis
3. Epstein Barr Virus
1997
1. Osteoporosis
2. Thrombophilia
3. Congenital Malformations
1998
1. Sickle Cell Disease
2. Hepatitis C
3. Chronic Myelogenous Leukemia
1999
1. Rheumatoid Arthritis
2. AIDS
3. Prostate Cancer
2000
1. Sickle Cell Disease
2. Epstein Barr Virus
3. Heart Failure
2001
1. Alzheimer’s Disease
2. Chronic Myelogenous Leukemia
3. SLE (Lupus)
2002
1. Heart Failure
2. Diabetes Mellitus
3. Preeclampsia
2003
1. SLE/Rheumatoid Arthritis
2. Chronic Myelogenous Leukemia
3. Asthma
2004
1. AIDS
2. Heart Failure
3. Preeclampsia
2005
1. Alzheimer’s Disease
2. Breast Cancer
3. Rheumatoid Arthritis
2006
1. Sickle Cell Anemia
2. Congestion Heart Failure
3. High Risk Pregnancy
2007
1. Rheumatoid Arthritis
2. Chronic Myelogenous Leukemia
3. Alzheimer’s Disease
2008
1. Cardio Disease/Heart Failure
2. Diabetes & Metabolism
3. Osteoporosis/Other Bone Disorders
2009
1. Sickle Cell Anemia
2. AIDS
3. Major Depressive Disorders
2010
1. Alzheimer’s Disease
2. Cardio Disease/Heart Failure
3. Diabetes
2011
1. Chronic Myelogenous Leukemia
2. Cystic Fibrosis
3. High Risk Pregnancy
2012
1. Rheumatoid Arthritis
2. Cardiovascular Disease
3. Malaria
2013
1. Diabetes
2. High Risk Pregnancy
3. Depression
2014
1. Translating Global Health
2. Cardiovascular Disease
3. Chronic Myelogenous Leukemia
2015
1. Immunotherapy
2. High Risk Pregnancy
3. Alzheimer’s Disease
2016
1. Evidence Based Medicine/Sickle Cell Disease
2. Diabetes
3. Cardiovascular Disease
​2017 ​​1. Immunotherapy
2. Alzheimer's Disease
3. Cardiovascular Disease
​2018 ​​1. High Risk Pregnancy
2. Pain Management
3. Cardiovascular Disease
​2019 ​​1. Immunotherapy
2. Diabetes
3. Retina

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