Noah Earland (MSTP in PhD training)

  • Oreland, PA

  • Southern Methodist University (2017)

  • Immunology

  • Aadel A. Chaudhuri, M.D., Ph.D.

  • Tumor microenvironment liquid biopsy for early immunotherapy response assessment



Aadel Chaudhuri (MD, PhD) whose lab group utilizes cell free DNA (cfDNA), extracted from the plasma of cancer patients, as a liquid biomarker to make inferences about minimal residual disease (MRD), treatment response, and treatment resistance in the context of solid tumors. The project I’m involved in directly utilizes tumor biopsy tissue with patient matched blood from colorectal cancer (CRC) and melanoma patients. The project seeks to define the expression profiles associated with cfDNA released from tumor invading leukocytes (TILs) prior to beginning immunotherapy. These expression profiles are compared against cfDNA from tumor naïve peripheral blood mononuclear cells (PBMCs) and cfDNA from tumor cells. In addition, I have helped establish a new project with collaborators at University of Missouri School of Medicine (UMSOM) to use cfDNA, circulating tumor cells (CTCs) and RNA-Seq to study the tumor microenvironment of non-small cell lung cancer (NSCLC).

Graduate Publications:

Szymanski JJ, Sundby RT, Jones PA, Srihari D, Earland N, Harris PK, Feng W, Qaium F, Lei H, Roberts D, Landeau M, Bell J, Huang Y, Hoffman L, Spencer M, Spraker MB, Ding L, Widemann BC, Shern JF, Hirbe AC, Chaudhuri AA. 2021 Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study. PLoS Med, 18(8):e1003734.

Pellini B, Pejovic N, Feng W, Earland N, Harris PK, Usmani A, Szymanski JJ, Qaium F, Mudd J, Petty M, Jiang Y, Singh A, Maher CA, Henke LE, Park H, Ciorba MA, Kim H, Mutch MG, Pedersen KS, Tan BR, Hawkins WG, Fields RC, Chaudhuri AA. 2021 ctDNA MRD Detection and Personalized Oncogenomic Analysis in Oligometastatic Colorectal Cancer From Plasma and Urine. JCO Precis Oncol, 5():PO.20.00276.

Last Updated: 8/15/2018 12:17:10 PM

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