Min Woo Kim (MSTP in PhD training)

  • Anaheim, CA

  • University of California-Los Angeles (2016)

  • Immunology

  • Jonathan Kipnis, Ph.D.

  • CNS autoantigens: a toggle between tolerance and autoimmunity

  • kim.minwoo@wustl.edu

Research

The focus of my project is to better understand central nervous system (CNS) autoantigens and their function in maintaining balance between autoimmune tolerogenic T cell states. Utilizing myelin oligodendrocyte glycoprotein (MOG)35-55 peptide immunization in C57BL/6 mice as my model for active experimental autoimmune encephalitis (EAE), I observed that immunizing myelin basic protein (MBP) together with MOG35-55 peptide in C57BL/6 mice could mildly suppress the EAE phenotype. Moreover, further analyses by flow cytometry unveiled increased cellularity of the draining lymph node as well as a notable increase in CTLA-4 expression on CD4+ T cells in the deep cervical lymph nodes when comparing between mice immunized with MOG35-55 and MBP together versus MOG35-55 alone. With implications that CTLA-4 has a role in altering T cell motility and controlling ligand expression on antigen presenting cells, it will be interesting to further explore the functionality of CTLA-4 in this context.  

Last Updated: 10/6/2021 9:23:06 PM

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