• University of Colorado-Boulder (2016)

  • Molecular Microbiology and Microbial Pathogenesis

  • David Sibley, Ph.D.

  • Investigating the molecular mechanisms of meiosis and centromere dynamics in the parasite Cryptosporidium parvum.

  • abigail.kimball@wustl.edu

Research

The apicomplexan parasite Cryptosporidium is a leading cause of infectious diarrhea in children and a significant threat to immunocompromised adults. Cryptosporidium has a complex life cycle that involves both asexual and sexual reproduction within a single host. Although the parasite can utilize asexual reproduction for autoinfection of the host intestine, sexual reproduction is required for the generation of infectious oocysts that facilitate disease transmission. Despite the essentiality of sex in its life cycle, very little is known about the overall process of meiosis in Cryptosporidium. Traditional in vitro culture methods support the asexual phase of the Cryptosporidium life cycle but inhibit sexual reproduction, and thus studies examining Cryptosporidium meiosis have historically been limited. A specialized spheroid culture system recently developed in our laboratory permits sexual reproduction of Cryptosporidium in vitro, providing a novel opportunity to examine the molecular mechanisms of meiosis in this medically relevant protist.

Last Updated: 7/7/2021 12:44:28 PM

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