Jessica Carpenter (MSTP in PhD training)

  • Virginia Beach, Virginia

  • Dartmouth College (2018)

  • Immunology

  • Deborah J. Lenschow, M.D., Ph.D.

  • Pathophysiology of Bronchiolitis Obliterans Syndrome in Chronic Lung Transplant Rejection

  • jessica.carpenter@wustl.edu

Research

This past summer I worked in the lab of Dr. Jennifer Alexander-Brett, MD PhD. I primarily worked on a project trying to understand the mechanism of chronic rejection in lung transplant patients. Lung transplant has the worst long-term outcomes of any transplantation surgery, with a median survival of 5.5 years post-transplant. The primary cause of death beyond the first year is bronchiolitis obliterans syndrome (BOS), which cannot be detected clinically until severe stages of disease. The pathophysiology of BOS is largely unknown, so my project focused on characterizing lung cells of human patients with BOS using RNAseq, qPCR, and immunofluorescence to gain insight into how the diseased cells are dysregulated. Understanding this pathophysiology could discover therapeutic targets as well as biomarkers of the disease before it is clinically apparent, leading to earlier therapeutic intervention and prevention of severe disease.

Last Updated: 9/17/2019 5:14:07 PM

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