Joshua Tobin (MSTP in PhD training)

  • Pittsburgh, Pennsylvania

  • Georgetown University (2018)

  • Immunology

  • Megan A. Cooper, M.D., Ph.D.

  • Novel primary immunodeficiency results in impaired B Cell memory

  • joshua.tobin@wustl.edu

Research

This past summer I worked in the lab of Megan Cooper, investigating the immunodeficiency in a family with recurrent pneumococcal vaccines. Additionally, despite normal antibody levels, affected individuals within the family cannot form specific responses to any vaccination. Through Next Generation sequencing, we discovered a large duplication in and around the immunoglobulin heavy chain locus, suggesting a B cell deficiency. I performed immunophenotyping suggesting a lack of memory B cells and optimized a proliferation and plasmablast generation assay to determine functional defects.

Last Updated: 9/19/2019 6:17:39 PM

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