• University of Delaware (2018)

  • Neurosciences

  • Erik S. Musiek, M.D., Ph.D.

  • Studying how the astrocyte circadian clock may regulate neutrophil infiltration into the CNS during different neurodegenerative diseases.

  • jenniferlawrence@wustl.edu


We propose a unique mechanism by which circadian regulation of CXCL5 in astrocytes allows for tight temporal and spatial control over BBB breakdown and leukocyte extravasation. CXCL5 is a potent chemokine that both induces BBB breakdown and neutrophil chemotaxis – two immune responses critical during neurodegeneration.

Last Updated: 7/21/2021 10:58:26 AM

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