Himadri B. Pakrasi, PhD

Freiberg Professor

Plant and Microbial Biosciences Program
Biochemistry, Biophysics, and Structural Biology Program
Molecular Genetics and Genomics Program

  • 314-935-6853

  • 314-935-6862

  • 314-935-6803

  • McDonnell Hall 045; Office: Green Hall 1160B

  • pakrasi@wustl.edu

  • https://sites.wustl.edu/photosynthbio/

  • Bioenergy, membrane proteins, photosynthesis, redox processes, systems biology, synthetic biology

  • Systems and Synthetic Biology of photosynthetic organisms

Research Abstract:

The Pakrasi Lab studies how cyanobacteria use solar energy to drive the chemistry of life.

We work in multiple disciplines and at many scales, studying how the molecular machines that capture solar energy are assembled and maintained, how cyanobacteria respond to changes in their environment at the systems level, and constructing new strains of cyanobacteria that can channel solar energy into biochemicals for human use.

Selected Publications:

Liu, D., Liberton, M., Yu, J., Pakrasi, H.B. and Bhattacharyya-Pakrasi, M. (2018) Engineering Nitrogen Fixation Activity in an Oxygenic Phototroph. mBio, 9(3), pii: e01029-18. doi: 10.1128/mBio.01029-18

Knoot, C. J., Ungerer, J. L., Wangikar, P. P. and Pakrasi, H. B. (2018) Cyanobacteria: Promising Biocatalysts for Sustainable Chemical Production. J. Biol. Chem. 293: 5044-5052.

Weisz, D. A., Gross, M. L. and Pakrasi, H. B. (2017) Reactive oxygen species leave a damage trail that reveals water channels in Photosystem II. Science Advances, 3(11): eaao3013. doi: 10.1126/sciadv.aao3013.

Lin, P.-C., Saha, R., Zhang, F. and Pakrasi, H. B. (2017) Metabolic engineering of the pentose phosphate pathway for enhanced limonene production in the cyanobacterium Synechocystis sp. PCC 6803. Scientific Rep., 7: 17503 | DOI:10.1038/s41598-017-17831-y.

Weisz, D. A., Liu, H., Zhang, H., Thangapandian, S., Tajkhorshid, E., Gross, M. L. and Pakrasi, H. B. (2017) Mass spectrometry-based cross-linking study shows that the Psb28 protein binds to cytochrome b559. Proc. Natl. Acad. Sci. USA, 114: 2224-2229.

Chen, H-Y. S., Liberton, M. Pakrasi, H. B. and Niedzwiedzki, D. M. (2017) Reevaluating the Mechanism of Excitation Energy Regulation in Iron-Starved Cyanobacteria. Biochim. Biophys. Acta, 1858: 249-258.

Ungerer, J.L. and Pakrasi, H.B. (2016) Cpf1 Is A Versatile Tool for CRISPR Genome Editing Across Diverse Species of Cyanobacteria. Scientific Rep., 6: 39681.

Saha, R., Liu, D., Hoynes-O`Connor, A., Liberton, M., Yu, J., Bhattacharyya-Pakrasi, M., Balassy, A., Zhang, F. Moon, T.-S., Maranas, C. D. and Pakrasi, H. B. (2016) A Systems Level Analysis of Diurnal Regulation of Cellular Processes in the Cyanobacterium Synechocystis sp. PCC 6803. mBio, 7: e00464-16..

Liberton, M., Saha, R., Jacobs, J. M., Nguyen, A. Y., Gritsenko, M. A., Smith, R. D., Koppenaal, D. W. and Pakrasi, H. B. (2016) Global Proteomic Analysis Reveals an Exclusive Role of Thylakoid Membranes in Bioenergetics of a Model Cyanobacterium. Mol. Cell. Proteomics, 15:2021-2032.

Liu, H., Zhang, H., Weisz, D. A., Vidavsky, I., Gross, M. L. and Pakrasi, H. B. (2014) Mass spectrometry based cross-linking analysis reveals the location of the PsbQ protein in cyanobacterial Photosystem II. Proc. Natl. Acad. Sci. USA, 111: 4638-4643.

Last Updated: 7/27/2018 11:25:55 AM

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