Ram Dixit, PhD

Professor
Biology

Plant and Microbial Biosciences Program
Molecular Cell Biology Program
Biochemistry, Biophysics, and Structural Biology Program

  • 314-935-8823

  • 314-935-9080

  • 314-935-4432

  • 245 McDonnell Hall

  • ramdixit@wustl.edu

  • https://sites.wustl.edu/dixitlab/

  • cytoskeleton, molecular motors, cell morphogenesis, cell wall biogenesis, plant biology

  • Molecular mechanisms of cytoskeleton organization and function

Research Abstract:

My lab is interested in understanding how different cell types acquire their characteristic shapes and how they are able to dynamically change form to adapt to prevailing conditions. Our work focuses on the cytoskeletal machinery that underlies these processes and seeks to uncover how noncentrosomal microtubules become organized into ordered patterns and how they define directional cell expansion. We use a synergistic combination of molecular genetics, live-imaging, in vitro biochemical reconstitution at single-molecule resolution, and computational modeling to discover new components and mechanisms underlying the complex and multi-scale process linking microtubule dynamics and organization to cell shape determination.

Mentorship and Commitment to Diversity Statement:
My lab is a close-knit and interactive team, with people pursuing a broad range of projects based on their interests. My goal is to train students to become creative and rigorous researchers, and to enable and support their engagement in career and professional development opportunities. I have worked hard to create a lab environment where all trainees feel welcome and empowered to pursue their chosen scientific career.

Selected Publications:

Calcutt R, Vincent R, Dean D, Arinzeh TL, and Dixit R (2021). Plant cell adhesion and growth on artificial fibrous scaffolds as an in vitro model for plant development. Science Advances. 7, eabj1469.

Ganguly A, Zhu C, Chen W and Dixit R (2020). FRA1 kinesin modulates the lateral stability of cortical microtubules through cellulose synthase-microtubule uncoupling proteins. Plant Cell. 32: 2508-2524.

Balkunde R, Foroughi L, Ewan E, Emenecker R, Cavalli V and Dixit R (2019). Mechanism of microtubule plus-end tracking by the plant-specific SPR1 protein and its development as a versatile plus-end marker. Journal of Biological Chemistry, 294: 16374-16384.

Burkart G and Dixit R (2019). Microtubule bundling by MAP65-1 protects against severing by inhibiting the binding of katanin. Molecular Biology of the Cell. 30: 1587-1597.

Fan Y, Burkart GM and Dixit R (2018). The Arabidopsis SPIRAL2 protein targets and stabilizes microtubule minus ends. Current Biology, 28: 987-994.

Nebenfuhr A and Dixit R (2018). Kinesins and myosins: molecular motors that coordinate cellular functions in plants. Annual Review of Plant Biology, Volume 69.

Ganguly A, DeMott L, Zhu C, McClosky DD, Anderson CT and Dixit R (2018). Importin-beta directly regulates the motor activity and turnover of a kinesin-4. Developmental Cell, 44: 642-651.

Zhu C, Ganguly A, Baskin TI, McClosky DD, Anderson CT, Foster C, Meunier KA, Okamoto R, Berg H and Dixit R (2015). The FRA1 kinesin contributes to cortical microtubule-mediated trafficking of cell wall components. Plant Physiology, 167: 780-792.

Zhang Q, Fishel EA, Bertroche T and Dixit R (2013). Microtubule severing at crossover sites by katanin generates ordered cortical microtubule arrays in Arabidopsis. Current Biology, 23: 2191-2195.

Last Updated: 11/17/2022 5:19:05 PM

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