Guy M. Genin, Ph.D.
Professor
Mechanical Engineering & Materials Science
Neurosurgery
Biochemistry, Biophysics, and Structural Biology Program
Developmental, Regenerative and Stem Cell Biology Program
Plant and Microbial Biosciences Program
314-973-4228
314-934-4014
Green Hall 3rd Floor
GENIN@WUSTL.EDU
www.cemb.org
mechanics, physics, interfaces, adhesion, mechanobiology, strain mapping, viscoelasticity
Interfaces and adhesions in physiology and nature
Research Abstract:
Interfaces and adhesions between materials present some of the greatest engineering challenges in nature, medicine, and structural design. My group studies how connections between dissimilar materials occur in nature, and applies this knowledge to propose and develop treatments and interventions. My group’s current thrust areas include adhesion of tendon to bone, interfaces within the heart in cardiomyopathy, and adaptive interfacial structures in plants. In each case, experimental and computational structural mechanics techniques and tools are at the core of our cross-disciplinary approaches.
Selected Publications:
Babaei, B., Velasquez-Mao, A.J., Pryse, K.M., McConnaughey, W.B., Elson, E.L. and Genin, G.M., 2018. Energy dissipation in quasi-linear viscoelastic tissues, cells, and extracellular matrix. Journal of the mechanical behavior of biomedical materials, 84, pp.198-207. https://doi.org/10.1016/j.jmbbm.2018.05.011
Linderman, S.W., Golman, M., Gardner, T.R., Birman, V., Levine, W.N., *Genin, G.M. and *Thomopoulos, S., 2018. Enhanced tendon-to-bone repair through adhesive films. Acta Biomaterialia, 70, pp.165-176.
Genin, G.M., Shenoy, V.B., Peng, Grace, and Buehler, M.J., 2017. Integrated Multiscale Biomaterials Experiment and Modeling. ACS Biomater. Sci. Eng. 3(11), pp 2628–2632.
Genin, G.M., and Thomopoulos, S., 2017. The tendon-to-bone attachment: Unification through disarray. Nature Materials, 16: pp.607-608.
Liu, S., Jiao, J., Lu, T.J., Xu, F., Pickard, B.G. and Genin, G.M., 2017. Arabidopsis Leaf Trichomes as Acoustic Antennae. Biophysical Journal, 113(9), pp.2068-2076.
Lipner, J., Boyle, J.J., Xia, Y., Birman, V., Genin, G.M. and Thomopoulos, S., 2017. Toughening of fibrous scaffolds by mobile mineral deposits. Acta Biomaterialia 58, pp. 492-501.
Jiang, Y., Pryse, K.M., Melnykov, A., Genin, G.M. and Elson, E.L., 2017. Investigation of nanoscopic phase separations in lipid membranes using inverse FCS. Biophysical Journal, 112(11), pp.2367-2376.
Deymier, A.C., Nair, A.K., Depalle, B., Qin, Z., Arcot, K., Drouet, C., Yoder, C.H., Buehler, M.J., Thomopoulos, S., Genin, G.M. and Pasteris, J.D., 2017. Protein-free formation of bone-like apatite: New insights into the key role of carbonation. Biomaterials, 127, pp.75-88.
Babaei, B., Velasquez-Mao, A.J., Thomopoulos, S., Elson, E.L., Abramowitch, S.D. and Genin, G.M., 2017. Discrete quasi-linear viscoelastic damping analysis of connective tissues, and the biomechanics of stretching. Journal of the Mechanical Behavior of Biomedical Materials. 69, 193-202.
Cheng, B., Lin, M., Huang, G., Li, Y., Ji, B., Genin, G.M., Deshpande, V.S., Lu, T.J. and Xu, F., 2017. Cellular mechanosensing of the biophysical microenvironment: A review of mathematical models of biophysical regulation of cell responses. Physics of Life Reviews. http://dx.doi.org/10.1016/j.plrev.2017.06.016
Last Updated: 7/27/2018 11:19:02 AM
The highly conserved ways that plant and animal cells feel, adapt, adapt to, and remember their mechanical environment are central themes of the NSF Science and Technology Center for Engineering MechanoBiology