Timothy A. Wencewicz, PhD

Associate Professor

Biochemistry, Biophysics, and Structural Biology Program
Plant and Microbial Biosciences Program
Molecular Microbiology and Microbial Pathogenesis Program

Research Abstract:

Infectious diseases continue to be a leading cause of death worldwide and the rapid development of bacterial resistance to current antibiotic chemotherapies is one of the world’s most urgent health problems. Stepping up to this challenge, our lab is dedicated to the discovery of new antibacterial scaffolds and drug delivery systems that act against underexploited biological targets and overcome known resistance mechanisms. Our inspiration for new antibiotic therapeutics comes from structurally diverse microbial natural products, "Nature’s Medicine", and relies on a coordinated effort of interdisciplinary approaches (organic synthesis, enzymology, spectroscopy, molecular biology, microbiology) to establish medicinal chemistry programs around unique, and sometimes complex, natural product molecular scaffolds.

Selected Publications:

Walsh, C. T.; Wencewicz, T. A. Prospects for new antibiotics: A molecule-­centered perspective. J. Antibiotics; Advanced Publication, June 12, 2013. DOI:10.1038/ja.2013.49.

Wencewicz, T. A.; Miller, M. J. Biscatecholate-­monohydroxamate mixed ligand siderophore-­carbacephalosporin conjugates are selective sideromycin antibiotics that target Acinetobacter baumannii. J. Med. Chem. 2013, 56, 4044-­4052.

Wencewicz, T. A.; Long, T. E.; Möllmann, U.; Miller, M. J. Trihydroxamate siderophore-­fluoroquinolone conjugates are selective sideromycin antibiotics that target Staphylococcus aureus. Bioconjugate Chemistry 2013, 24, 473-­486.

Last Updated: 12/16/2013 3:38:59 PM

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